The Etiology of Alzheimer’s Disease Reveals Potential Applications for Precision-Based Gene Therapy Utilizing the CRISPR/Cas9 Protocol To Counter Mechanisms of Pathogenesis

The Etiology of Alzheimer’s Disease Reveals Potential Applications for Precision-Based Gene Therapy Utilizing the CRISPR/Cas9 Protocol To Counter Mechanisms of Pathogenesis

The CRISPR-Cas9 genome-editing system is a part of the adaptive immune system in archaea and bacteria to defend against invasive nucleic acids from phages and plasmids. The guide RNA (sgRNA) of the system recognizes its target sequence in the genome, and the Cas9...
ACL Recovery Inequality: Socioeconomic Status and Injury Recuperation

ACL Recovery Inequality: Socioeconomic Status and Injury Recuperation

Anterior cruciate ligament (ACL) injury is commonplace amongst athletes and individuals alike, yet despite its frequency, this injury devastatingly increases morbidity and greatly impacts one’s day-to-day schedule (1). ACL injuries comprise up to 50% of ligamentous...
Epidemiological Analysis of the Relationship Between Lower Back Pain Incidence and Implementation of Occupational Preventative Measures

Epidemiological Analysis of the Relationship Between Lower Back Pain Incidence and Implementation of Occupational Preventative Measures

Roughly 60 to 80% of individuals in the United States population have experienced lower back pain at some point in their life [1]. Lower back pain (LBP) is generally defined as pain, muscle tension, or stiffness localised below the costal margin and above the inferior...
Racial Disparities in Individuals Presenting with Knee Injuries Seeking Total Knee Arthroplasty/Total Joint Replacement Procedures

Racial Disparities in Individuals Presenting with Knee Injuries Seeking Total Knee Arthroplasty/Total Joint Replacement Procedures

Total Knee Arthroplasty (TKA) and Total Joint Replacement (TJR) procedures are customarily used to surgically reconstruct or replace a joint. This procedure is frequently performed as a resolution for functional debilitation in the knee and knee pain management....